Soon Jae Park;Ji-Sun Kim;Sang Mee Lee;Hye-Shin Chung
发明人:
Soon Jae Park,Hye-Shin Chung,Sang Mee Lee,Ji-Sun Kim
申请号：
US14344468
公开号：
US09051395B2
申请日:
2012.08.13
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A novel alpha-1 antitrypsin variant, a method of preparing the same, and use thereof are provided. The alpha-1 antitrypsin variant has excellent stability in the body and maintains an inhibitory effect on elastase activities because the blood half-life (t1/2) and the area under blood drug concentration vs. time curve (AUC) are remarkably increased by adding an N-glycosylation site in animal cells through amino acid mutation between 1st and 25th positions of the N-terminus of alpha-1 antitrypsin. Therefore, the alpha-1 antitrypsin variant can be useful in preventing or treating alpha-1 antitrypsin deficiency.
