Invention relates to a solid form of dosage with controlled release to apply orally, containing analgetically efficient quantity of oxycodone or some of the salts thereof in a matrix case, where the speed of solution release form in vitro measured in so called USP Paddle method at 100 -1 in 900 ml water solution of buffer stop (pH between 1,6 and 7,2) at 37°C between 12,5 and 42,5 % (mass) oxycodone released upon one hour, between 25 and 55 % (mass) oxydocone released upon 2 hours, between 45 and 75% (mass) oxycodone released upon 4 hours, and between 55 and 85 % (mass) oxycodone released upon 6 hours, where the release speed in vitro is actually independent of pH when pH is between 1,6 and 7,2. That form of dosage is achieved in the form of a pill. The invention herewith relates to the procedure for preparation of such an orally form of controlled release.Pronalazak se odnosi na &ccaronvrst oblik doziranja sa kontrolisanim ispu&scarontanjem za oralno davanje, koji sadr&zcaroni analgetski efikasnu koli&ccaroninu oksikodona ili neke njegove soli u jednoj matrici, pri &ccaronemu je brzina rastvaranja oblika doziranja in vitro mereno tzv. Postupkom pomo&cacuteu lopatica (USP Paddle Method) pri 100 min-1 u 900 ml vodenog rastvora pufera (pH izmedju 1,6 i 7,2) na 37В°C, izmedju 12,5 i 42,5% (mas) oksikodona ispu&scarontenog posle 1 &ccaronasa, izmedju 25 i 55% (mas) oksikodona ispu&scarontenog posle 2 &ccaronasa, izmedju 45 i 75% (mas) oksikodona ispu&scarontenog posle 4 &ccaronasa i izmedju 55 i 85% (mas) oksikodona ispu&scarontenog posle 6 &ccaronasova, pri &ccaronemu je brzina ispu&scarontanja in vitro u su&scarontini nezavisna do pH kada je pH izmedju 1,6 i 7,2. Taj oblik doziranja je izveden u vidu tablete. Pronalazak se takodje odnosi na postupak za pripremanje takvog oralnog oblika doziranja.[Invention relates to a solid form of dosage with controlled release to apply orally, containing analgetically efficient quantity of oxycodone or some of the salts thereof in
