The present invention discloses a kind of lactobacillus composition, include a lactobacillus reuteri (Lactobacillus.reuteri) GMNL-263, wherein lactobacillus reuteri (Lactobacillus.reuteri) the GMNL-263 system is that heat kills dead bacterium, inflammatory cell hormone IL-1 β is inspired through inhibition one and promotes the growth of a Bifidobacterium, and there is the effect of blood pressure lowering, which is medical composition, nutriment, health food or combinations thereof.本發明公開一種乳桿菌組合物，包含一羅伊氏乳桿菌(Lactobacillus.reuteri)GMNL-263，其中該羅伊氏乳桿菌(Lactobacillus.reuteri)GMNL-263係為熱滅殺死菌，透過抑制一促發炎細胞激素IL-1β與提升一雙歧桿菌屬的生長，而具有降血壓之功效，該乳桿菌組合物為醫藥組合物、營養補充品、保健食品或其組合。
