TAIPEI MEDICAL UNIVERSITY;CHINA MEDICAL UNIVERSITY
发明人:
WU, CHIEH HSI,吴介信,吳介信,KUO, YUEH HSIUNG,郭悦雄,郭悅雄,PAN, CHUN HSU,潘俊旭,潘俊旭
申请号：
TW104118239
公开号：
TWI664170B
申请日:
2015.06.04
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present invention develops a series of methyl caffeate derivatives having biological activity in anti-angiogenesis. The present invention suggests that the compounds of the invention possess inhibiting angiogenesis through regulation of VEGF/VEGFR-2 and its downstream signaling cascades in the vascular endothelial cells (VECs).本發明發展一種在抗血管生成中具有生物活性之一系列咖啡酸甲酯衍生物。本發明表明本發明化合物在血管內皮細胞(VEC)中經由調節VEGF/VEGFR-2及其下游信號級聯作用來抑制血管生成。
