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NEW DOSE AND PREPARATION FORM
专利权人:
АЛЬМИРАЛЬ; С.А. (ES)
发明人:
ЛАМАРКА-КАСАДО Роса (ES),ДЕ-МИКЕЛЬ-СЕРРА Гонсало (ES)
申请号:
RU2010141333/15
公开号:
RU2010141333A
申请日:
2009.03.13
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A pharmaceutical composition for inhalation containing aclidinium in the form of a dry powder of a pharmaceutically acceptable salt mixed with a pharmaceutically acceptable carrier in the form of a dry powder, which contains a measured nominal dose of aklidinium equivalent to about 400 μg of aklidinium bromide. ! 2. The pharmaceutical composition according to claim 1 in the form of a single dose formulation in the form of a dry powder containing one measured nominal dose of aclidinium equivalent to about 400 μg of aclidinium bromide. ! 3. The pharmaceutical composition according to claim 1 in the form of a multidose formulation in the form of a dry powder, intended for administration with a multidose inhalation device for dry powder, which is calibrated to ensure the introduction of a measured nominal dose of aklidinium equivalent to about 400 μg of aklidinium bromide. ! 4. The pharmaceutical composition according to one of the preceding paragraphs, in which the pharmaceutically acceptable salt of aclidinium is aclidinium bromide. ! 5. The pharmaceutical composition according to claim 1, wherein the pharmaceutically acceptable carrier is lactose particles. ! 6. The pharmaceutical composition according to claim 1, in which the mass ratio of aclidinium and carrier is from 1:25 to 1:75. ! 7. The pharmaceutical composition according to claim 6, in which the mass ratio of aklidinium and carrier is from 1:50 to 1:75. ! 8. The pharmaceutical composition according to claim 1, in which the average particle diameter of aklidinium is 2-5 microns. ! 9. The pharmaceutical composition according to claim 1, in which the carrier particles are characterized by a dl0 value of 90-160 μm, a d50 value of 170-270 μm, and a d90 value of1. Фармацевтическая композиция для ингаляции, содержащая аклидиний в форме сухого порошка фармацевтически приемлемой соли в смеси с фармацевтически приемлемым носителем в форме сухого порошка, которая содержит отмеренную номинальную дозу аклидиния, эквив
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