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Pharmaceutical formulation and process comprising a solid dispersion of macrolide (tacrolimus)
专利权人:
Greg A. Brubaker
发明人:
Greg A. Brubaker,Thomas D. Mahon
申请号:
US12101500
公开号:
US08222272B2
申请日:
2008.04.11
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a pharmaceutical formulation and process for preparing the same comprising an oral dosage formulation, such as a capsule formulation, of a macrolide compound, such as tacrolimus, wherein the capsule formulation contains both a solid dispersion of the macrolide along with a non-dispersed form of the macrolide. The pharmaceutical formulation according to the invention is bioequivalent to the FDA approved product according to a bioavailability study conducted in humans.
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