An atherectomy system (100) comprises a catheter body (112, 210) extending from a proximal catheter portion (114) to a distal catheter portion (116). The catheter body includes an aspiration lumen (400) extending from the distal catheter portion to the proximal catheter portion. The atherectomy system further comprises an atherectomy assembly (200) coupled with the distal catheter portion, wherein the atherectomy assembly includes a rotatable cutter (204), and a drive shaft (324) coupled with the rotatable cutter and extending to the proximal catheter portion. The atherectomy system comprises a shaft sleeve (412) extending through the aspiration lumen and surrounding the drive shaft, wherein the draft shaft is rotatable relative to the shaft sleeve, and wherein the shaft sleeve isolates the drive shaft from the aspiration lumen. The atherectomy system further comprises a jet body (212) positioned within the aspiration lumen near the catheter distal portion, wherein the jet body includes at least one jet orifice (500) directed proximally through the aspiration lumen, and an inflow orifice (216) extending through the catheter body and in communication with the aspiration lumen, wherein the inflow orifice is adjacent to and downstream from the jet body.
