Philip P. Connell,Brian Budke,Jay H. Kalin,Michal Pawlowski,Alan P. Kozikowski
申请号：
US14648115
公开号：
US20150306069A1
申请日:
2013.11.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
