Compounds derived from 4 - (Diphenyl - 3 - yl) - 7H - imidazo [4,5-c] pyridazine hydrochloride, modulators of the Gabaa receptor activity； Pharmaceutical composition that comprises； a combination that includes a pharmaceutically ACTIVE AGENT and second； method of treatment of Pain and its use for trafficking； Treatment of pain.
OMOTO, KIYOYUKI,OWEN, ROBERT MCKENZIE,PRYDE, DAVID CAMERON,WATSON, CHRISTINE ANNE LOUISE,TAKEUCHI, MIFUNE
申请号：
CL2015001652
公开号：
CL2015001652A1
申请日:
2015.06.12
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.<；p>；Se describen compuestos derivados de 4-(bifenil-3-il)-7H-imidazo[4,5-c]piridazina de acuerdo con la Fó；rmula (I), o una sal farmacé；uticamente aceptable del mismo, una composició；n y combinació；n farmacé；utica que lo comprende junto a un segundo agente activo, ademá；s de su uso en el tratamiento del dolor.<；/p>；
