abstract human antibodies immunospecific for human cd27 are capable of blocking cd27 binding to its ligand cd70 and neutralizing bioactivity of cd27 including, but not limited to, cd27 intracellular signaling, t-cell proliferation and activation, b-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by cd70, and the production of soluble mediators from t and b-cells. antibodies are useful in diagnosing or treating cd27 activity associated diseases and conditions. "anti-human cd27 antibodies, methods and uses" immunospecific human antibodies to human cd27 are capable of blocking cd27 binding to its cd70 ligand and neutralizing cd27 bioactivity including but not limited to , cd27 intracellular signaling, t-cell activation and proliferation, b-cell differentiation and proliferation, plasmablast formation and alleviation of antibody responses, cd70-stimulation of tumor cells, and production of soluble mediators. from te cells b. Antibodies are useful in the diagnosis or treatment of diseases and conditions associated with cd27 activity.abstract human antibodies immunospecific for human cd27 are capable of blocking cd27 binding to its ligand cd70 and neutralizing bioactivity of cd27 including, but not limited to, cd27 intracellular signaling, t-cell proliferation and activation, b-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by cd70, and the production of soluble mediators from t and b-cells. the antibodies are useful in diagnosing or treating cd27 activity associated diseases and conditions. tradução do resumo resumo patente de invenção "anticorpos anti-cd27 humanos, métodos e usos" os anticorpos humanos imunoespecíficos para cd27 humana são capazes de bloquear a ligação de cd27 a seu ligante cd70 e neutralizar a bioatividade de cd27 incluindo, mas não se limitando a, a sinalização intracelular de cd27, a ativação
