In the present invention, a system and associated method is provided for image-guided navigation during a medical procedure. The system includes a movable gantry having an X-ray source, an X-ray detector and a laser disposed on the detector offset from the area of the detector receiving the beam from the source, a movable table and a system controller operably connected to the gantry, the X-ray source, the X-ray detector, the laser and the table. In the method, the controller determines an optimal trajectory for the insertion of an interventional device into the body to intersect the target, positions the gantry to locate the laser at a point where a laser beam is emitted from the laser along the optimal trajectory outside of the X-ray beam, and takes additional images during the procedure to show the position of the interventional device in the body as compared with the optimal trajectory.
