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SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-(PYRROLIDIN-3-YLVINYL)PYRIMIDINE
专利权人:
TARGACEPT; INC.
发明人:
AKIREDDY, SRINIVISA RAO,MILLER, CRAIG, HARRISON,BHATTI, BALWINDER, SINGH,MUNOZ, JULIO, A,DULL, GARY, MAURICE,MITCHENER, JOSEPH, PIKE, JR
申请号:
NZ59255409
公开号:
NZ592554A
申请日:
2009.11.30
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
Abstract 592554 The present disclosure relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine crystalline salt forms, and novel polymorphic forms of these salts.the crystalline acid addition salts of the disclosure include salts wherein the acid is selected from hydrochloric, sulfuric, methanesulfonic, maleic, phosphoric, I-hydroxy-2-naphthoic, ketoglutaric, malonic, L-tartaric, fumaric, citric, L-malic, hippuric, L-lactic, benzoic, succinic, adipic, acetic, nicotinic, propionic, orotic, 4-hydroxybenzoic, di-p-toluoyl-D-tartaric, di-panisoyl- D-tartaric, di-benzoyl-D-tartaric, 10-camphorsulfonic, camphoric, and phencyphos.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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