An extended release oral administered dosage form of acetaminophen and tramadol. The dosage form includes a composition of acetaminophen together with a tramadol complex formed with an anionic polymer. The tramadol complex provides sustained release of tramadol for a synchronized (coordinated) release profile of acetaminophen and tramadol.一種乙醯胺酚及曲馬多的緩釋口服實施劑型。該劑型包含一種乙醯胺酚組合物,其伴隨有一種由陰離子聚合物所組成的曲馬多錯合物。該曲馬多錯合物提供緩釋的曲馬多,形成乙醯胺酚及曲馬多同步的(協調的)釋放曲線。