The United States of America, as represented by the Secretary, Department of Health and Human;University of Maryland, College Park
发明人:
Scott Durum,Julie Hixon,Wen Qing Li,Scott Walsh,Lila Kashi
申请号：
US15760193
公开号：
US20180251561A1
申请日:
2016.10.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Antibodies and antigen binding fragments that specifically bind to IL-7Rα are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7Rα using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7Rα, such as acute lymphoblastic leukemia.
