compound of formula (i), compound of formula (ia), compound of formula (ic), compound of formula (ii), compound of formula (iia), compound, method for treating a hyperproliferative disorder in a mammal, which includes a human, method for treating a inflammatory disease, condition, or disorder in a mammal, which includes a human, method for treating a disorder or condition that is modulated by the meik cascade in a mammal, which includes a hyman, method for treating or prevent cancer, pharmaceutical composition and method to inhibit a mek enzyme
The invention pertains to compound of Formula (I) wherein X, Y, Z, R1, R2, R3, R4, A and A&prime； are as described hereinabove. Formula (I) and (II) compounds can be used in pharmaceutical compositions, useful for the treatment of diseases.
