Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNsin vivo. In some embodiments, the compounds disclosed herein are ENPP-1 inhibitors, pharmaceutical compositions, and methods for the treatment of cancer or a viral infection.本文揭示強化及增強活體內I型IFN產生的方法及化合物。在一些實施例中,本文所揭示之化合物為用於治療癌症或病毒感染的ENPP-1抑制劑、醫藥組合物及方法。