PROBLEM TO BE SOLVED: To provide an agent and composition for the prevention or treatment of metabolic bone disease, that can effectively prevent or treat metabolic bone disease with bone loss.SOLUTION: The present invention provides an agent and composition for the prevention or treatment of metabolic bone disease with bone loss that contains latent Transforming growth factor (TGF)-β3 or latent TGF-β1 as an active ingredient.SELECTED DRAWING: None【課題】骨量の減少を伴う骨代謝性疾患を効果的に予防又は治療することができる、予防又は治療剤、及び予防又は治療用組成物を提供する。【解決手段】潜在型Ｔｒａｎｓｆｏｒｍｉｎｇ ｇｒｏｗｔｈ ｆａｃｔｏｒ（ＴＧＦ）－β３又は潜在型ＴＧＦ－β１を有効成分として含有する、骨量の減少を伴う骨代謝性疾患の予防又は治療剤、及び予防又は治療用組成物。【選択図】なし
