The present invention provides a kind of artificial cerebrospinal fluid, it contains 120 ~ 160mEq/L of sodium ion, 1 ~ 6mEq/L of potassium ion, 75 ~ 155mEq/L of chloride ion, 5 ~ 45mEq/L of bicarbonate ion, a kind of artificial cerebrospinal fluid is also provided, it includes be selected from least one of 10g/L reduced sugars below, 5mmol/L phosphoric acid below, 5mEq/L calcium ions below, 5mEq/L magnesium ions below ingredient. Artificial cerebrospinal fluid of the invention is used as the replenisher of cleaning solution or perfusate or the celiolymph of forfeiture that the neuro-surgeries fields such as encephalic operation use, can prevent or lower the generation of brain edema, can also inhibit the cellular damage of brain cell.本發明提供一種人工髓液,其含有鈉離子120~160mEq/L、鉀離子1~6mEq/L、氯離子75~155mEq/L、碳酸氫根離子5~45mEq/L,還提供一種人工髓液,其包含選自10g/L以下的還原糖、5mmol/L以下的磷酸、5mEq/L以下的鈣離子、5mEq/L以下的鎂離子中的至少一種成分。本發明的人工髓液用作顱內手術等腦神經外科領域使用的清洗液或灌流液、或者喪失的腦脊髓液的補充液,能够防止或减低腦水腫的發生,還可以抑制腦細胞的細胞損傷。