ROETH, JEREMIAH F.,REED, CHARLES C.,CUTHBERTSON, BRANDON,CHADA, SUNIL,FOGLER, WILLIAM E.
申请号:
EP11760175
公开号:
EP2550359A4
申请日:
2011.03.23
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immunomodulators or therapeutic proteins under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, infectious diseases, ocular diseases, lysosomal storage diseases, or liver diseases, through direct injection or through in vitro engineered cells, such as dendritic cells.