Yan Lou;Zachary Kevin Sweeney;Eric Brian Sjogren;Michael Soth;Nolan James Dewdney
发明人:
Nolan James Dewdney,Yan Lou,Eric Brian Sjogren,Michael Soth,Zachary Kevin Sweeney
申请号：
US12459595
公开号：
US08536166B2
申请日:
2009.07.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This application discloses 5-phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-V:wherein, variables Q, R, Y1, Y2, Y2′, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.
