Systems and methods for performing ultrasound imaging. Main channel domain data for performing ultrasound imaging of a subject area for performing ultrasound imaging of the subject area is collected. Further, region of interest (“ROI”) channel domain data for performing ultrasound imaging of a ROI within the subject area is collected. One or more ultrasound images of the subject area can be formed using the main channel domain data. Additionally, one or more ROI ultrasound images of the ROI within the subject can be formed independently from the one or more main ultrasound images of the subject area using the ROI channel domain data of the ROI within the subject area. Subsequently, the one or more ROI ultrasound images can be displayed concurrently with the one or more main ultrasound images.