CHEN FRANCINE ZHIFEN,JOHNSON LESLIE S.,LOO DERYK T.,MOORE PAUL A.,HUANG LING
申请号：
NZ60216111
公开号：
NZ602161A
申请日:
2011.03.01
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Discloses a B7-H3 antibody which comprises three heavy and three light chain CDR&rsquos and that specifically binds to an extracellular domain of B7-H3, wherein said molecule (A) binds to 4Ig and 2Ig isoforms of B7-H3 that is endogenously expressed on the surface of a cancer cell (B) is internalized upon binding to B7-H3 expressed on the surface of the cancer cell and (C) comprises a variable domain that comprises the CDR sequences of RASQDISNYLN, YTSRLHS, QQGNTLPPT, SYWMQ, TIYPGDGDTRYTQKFKG and RGIPRLWYFDV.
