Disclosed is the combination of beta-hydroxy-beta-methylbutryate, arginine, and glutamine for use in a method of treating a diabetic ulcer in a diabetic individual having at least one of: (a) a serum albumin level of less than or equal to 4.0 g/dL, and/or (b) an Ankle-Brachial Index of less than 1.0. 9. Also disclosed is the use of the combination of beta-hydroxy-beta-methylbutryate, arginine, and glutamine for the manufacture of a medicament for use in the treatment of a diabetic ulcer in a diabetic individual having at least one of: (a) a serum albumin level of less than or equal to 4.0 g/dL, and/or (b) an Ankle-Brachial Index of less than 1.0. In certain embodiments, the combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine are orally administered via a nutritional composition.本發明揭示β-羥基-β-甲基丁酸鹽、精胺酸及麩醯胺酸之組合，其用於治療出現以下至少一項之糖尿病個體之糖尿病性潰瘍之方法中：(a)血清白蛋白含量小於或等於4.0 g/dL，及/或(b)踝-肱指數(Ankle-Brachial Index)小於1.0。本發明亦揭示β-羥基-β-甲基丁酸鹽、精胺酸及麩醯胺酸之組合之用途，其用於製造用於治療出現以下至少一項之糖尿病個體之糖尿病性潰瘍之藥劑：(a)血清白蛋白含量小於或等於4.0 g/dL，及/或(b)踝-肱指數小於1.0。在某些實施例中，β-羥基-β-甲基丁酸鹽、精胺酸及麩醯胺酸之該組合係經由營養組合物經口投與。
