Use of human small leucine zipper protein in adipocyte differentiation procedure

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专利权人:

发明人:

Je Sang Ko,Jeong-Han Kim

申请号：

US15692789

公开号：

US10058586B2

申请日:

2017.08.31

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to a use of a human small leucine zipper protein in the adipocyte differentiation procedure. More specifically, sLZIP binds with PPARγ2 to induce the formation of a complex of HDAC3 and PPARγ2, thereby functioning as a corepressor to negatively inhibit the transcriptional activity of PPARγ2 and suppress the differentiation to adipocytes, and thus can be used as a marker for treating diabetes and obesity and developing new medicines therefor.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/