PROCESS FOR PREPARATION OF MACITENTAN

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专利权人:

发明人:

HIRPARA SANJAY,TRIPATHI CHANDRESH KUMAR,GOUD RAJAVARDHAN,AKSHAY KANT CHATURVEDI

申请号：

IN201641015598

公开号：

IN201641015598A

申请日:

2016.05.04

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

The present invention relates toaprocess for the preparation of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4- pyrimidinyl]-Npropylsulfamide or Macitentan of Formula (I). (I) The present invention further relates to a process for the preparation highly pure N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-Npropylsulfamide or Macitentan of Formula (I). Said substantially pure Macitentan is useful in the preparation of pharmaceutical composition for the treatment of cardiac disorders.

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