The present invention provides multivalent and multispecific binding proteins that are capable of binding two or more antigens, or two or more epitopes. The present invention also provides methods of making and using such multivalent and multispecific binding proteins, including methods of using such binding proteins for prevention or treatment of various diseases, or for detecting specific antigens in vitro or in vivo.本發明提供能夠結合兩個或更多個抗原或者兩個或更多個抗原決定基之多價及多特異性結合蛋白質。本發明亦提供製造及使用此種多價及多特異性結合蛋白質之方法,包括使用此種結合蛋白質用於預防或治療多種疾病,或用於在活體外或活體內偵測特定抗原之方法。
