PHILLIPS, Andrew J.,NASVESCHUK, Chris G.,HENDERSON, James A.,LIANG, Yanke,LAZARSKI, Kiel,MICHAEL, Ryan E.
申请号:
EP17796800
公开号:
EP3454862A4
申请日:
2017.05.10
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.