A skin securable infusion assembly includes a housing having a skin contacting adhesive layer and supporting an infusion cannula. An elongate tubular reservoir having a plunger slidably disposed therein is configured to contain a supply of liquid medication between a distal opening of the reservoir and the plunger. The reservoir has an assembled configuration in which the reservoir is supported on the housing. An actuation mechanism is coupled with the plunger and, when the reservoir is in the assembled configuration, an actuation of the actuation mechanism moves the plunger toward the distal opening and forces a portion of the liquid medication through the distal opening and into the infusion cannula.
