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Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
专利权人:
OM PHARMA
发明人:
CHIAVAROLI, CARLO,BAUER, JACQUES,MOUTEL, STEPHANE
申请号:
AU2007222135
公开号:
AU2007222135B2
申请日:
2007.03.09
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention relates to the use of immunomodulatory compounds for the treatment of diseases related to to an overproduction of inflammatory cytokines, such as diseases selected from the group consisting of asthma, atopic dermatitis, allergic rhinitis, prostatitis, inflammatory bowel disease, diabetes, and rhumatoid arthritis, said compounds being of general formula (I), wherein : m and n, independently from each other, are an integer ranging from 1 to 4, X and Y represent -COOH, -0-P(O)(OH), -O-SO(OH), -NH, -OH, -CONH(CH)-NH, -CO-NH-CH(COOH)-(CH)COOH, -CO-NH-CH(COOH)- (CH2)-NH, -O-CO-(CH)-NH,-O-CO-(CH)-CHOH-CHOH, -O-CO-(CH)-OH, -O-CO-(CH)-COOH, -O-CO-(CH)-CHO, -O-CO-(CH)-NH-CO-(CH)-COOH, R and R each designate an acyl group derived from a saturated or unsaturated, straight-or branched-chain carboxylic acid having from 2 to 18 carbon atoms, which is unsubstituted or bears one to three substituents selected among hydroxyl, dihydroxyphosphoryloxy, alkyl of 2 to 18 carbon atoms, alkoxy of 2 to 18 carbon atoms, acyloxy of 2 to 18 carbon atoms in the acyl moiety, amino, acylamino.
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