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GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS
专利权人:
EXOSTEM BIOTEC LTD.
发明人:
Chaya BRODIE
申请号:
US15794137
公开号:
US20180142208A1
申请日:
2017.10.26
申请国别(地区):
US
年份:
2018
代理人:
摘要:
A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating a population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.
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