HIGHLY DISPERSIBLE GRANULATE FOR THE PREPARATION OF FORMULATIONS OF HIGH DOSAGE ACTIVE SUBSTANCES AND PROCEDURE FOR OBTAINING HIGH DOSAGE ACTIVE SUBSTANCES THEREOF
Jose Antonio Matji Tuduri,Antonio Matji Arroquia,Luis Carvajal Martin
申请号：
US13643824
公开号：
US20130108699A1
申请日:
2010.04.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
By mixing ibuprofen and a disaggregating agent, the invention involves using these components in a proportion ranging between 96% and 97% by weight for ibuprofen, and between 3% and 4% for the disaggregating agent, which may be Sodium croscarmellose, Crospovidone or Sodium carboxymethyl starch, as well as a mixture thereof. Following the mixing of the raw materials, the mixture is subjected to compaction, granulation and subsequent compression, in order to finally give the tablet a coating this leads to a significant cost reduction and a significant reduction in the active principle release time, such that the pharmacological action is very fast in time.
