A method and system for determining system-based tumor burden is disclosed. In one aspect, the method includes obtaining the medical image from a source, through an interface. Additionally, the method includes identifying a first region of interest in the medical image. The method also includes selecting from the first region of interest a second region of interest whose tumor burden is to be determined. Furthermore, the method includes defining a segmentation criterion for the second region of interest. The method also includes determining the tumor burden for the second region of interest.
