An adjustable polarity laser device may treat cancer and other conditions that are responsive to polarized laser energy. The device provides both low-level laser and electrical stimulation of a treatment area, such as a tumor to promote the bodys natural defense systems against harmful cells in the treatment area. The device produces low-level laser beams that are polarized with either birefringent or electrically conductive materials disposed in the path of the laser beams. Electrically conductive polarizers are charged by an electric current to impart polarity on the passing laser beams. Treatment methods include applying polarized laser energy to the targeted treatment area. The polarization of each laser beam may be selected and alternated as necessary for the condition being treated. Additionally, photodynamic compounds or photosensitizing agents can be administered to the patient prior to applying polarized laser energy.