A method for diagnosing or treating an immune disorder in a subject is disclosed. The method is based on the detection or modulation of a refractory state inducing factor (RIF). [Selection figure] None【課題】対象における免疫障害を診断又は処置するための方法が開示される。【解決手段】該方法は、不応状態誘導因子(Refractory State Inducing Factor、RIF)の検出又は調節に基づく。【選択図】なし