JUSTIN K. MURRAY,LESLIE P. MIRANDA,STEFAN I. MDONOUGH
申请号：
ARP120100896
公开号：
AR088413A1
申请日:
2012.03.19
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
It describes an ingredient that includes an isolated polypeptide, an externally restricted Nav1.7 inhibitor. In some published results, isolated peptides are inhibitors of Nav1.7 and / or Nav1.3. Other achievements include the incorporation of pharmaceutical ingredients and components. Some isolated nucleic acids are reported, and some polypeptide achievements, expression vectors and host cells containing these substances are encoded. In addition, it also introduces the methods of treatment or prevention of pain. Requirement 1: composition of the substance,which comprises an isolated polypeptide comprising the amino acid sequence of the formula: Xₐₐ¹Xₐₐ²Xₐₐ³Xₐₐ⁴Xₐₐ⁵Xₐₐ⁶Xₐₐ⁷Xₐₐ⁸Xₐₐ⁹Xₐₐ¹⁰Xₐₐ¹¹Xₐₐ¹²Xₐₐ¹³Xₐₐ¹⁴Asp¹⁵Xₐₐ¹⁶Xₐₐ¹⁷Xₐₐ¹⁸Xₐₐ¹⁹Xₐₐ²⁰Xₐₐ²¹Xₐₐ²²Xₐₐ²³Xₐₐ²⁴Xₐₐ²⁵Xₐₐ²⁶Xₐₐ²⁷Xₐₐ²⁸Xₐₐ²⁹Xₐₐ³⁰Xₐₐ³¹Lys³²Xₐₐ³³Xₐₐ³⁴Xₐₐ³⁵Xₐₐ³⁶Xₐₐ³⁷Xₐₐ³⁸ // SEQ ID No. 475 or a pharmaceutically acceptable salt thereofwhere: Xₐₐ¹Xₐₐ² is absent； or Xₐₐ¹ is an amino acid residue and Xₐₐ² is an amino acid residue； or Xₐₐ¹ is absent and Xₐₐ² is an amino acid residue； Xₐₐ³ is Cys, if Xₐₐ¹⁸ is Cys； or Xₐₐ³ is SeCys, if Xₐₐ¹⁸ is SeCys； or Xₐₐ³ is an alkyl amino acid residue, if Xₐₐ¹⁸ is an alkyl amino acid residue； Xₐₐ⁴ is an acidic, hydrophobic, basic, or neutral hydrophilic amino acid residue； Xₐₐ⁵ is a Gly, Ala, hydrophobic or basic amino acid residue； Xₐₐ⁶ is a Gly, Ala, 2-Abu, Nle, Nva, or hydrophobic amino acid residue； Xₐₐ⁷ is a Gly, Ala, aromatic or hydrophobic amino acid residue；Xₐₐ⁸ is a basic hydrophilic, acidic, or neutral amino acid residue, or an Ala residue； Xₐₐ⁹ is a neutral or basic hydrophilic amino acid residue； Xₐₐ¹⁰ is Cys if Xₐₐ²⁴ is Cys； or Xₐₐ¹⁰ is SeCys if Xₐₐ²⁴ is SeCys； Xₐₐ¹¹ is any amino acid residue； Xₐₐ¹² is a Pro, acidic, neutral or hydrophobic amino acid residue； Xₐₐ¹³ is any amino acid residue； Xₐₐ¹⁴ is any amino acid residue； Xₐₐ¹⁶ is a basic, neutral hydrophilic, or acidic amino acid residue, or an Ala residue； Xₐₐ¹⁷ is Cys if Xₐₐ³¹ is Cys； or Xₐₐ¹⁷ is SeCys if Xₐₐ³¹ is
