COMPOSITIONS, DEVICES AND METHODS FOR DIAGNOSING HEART FAILURE AND FOR PATIENT-SPECIFIC MODELING TO PREDICT OUTCOMES OF CARDIAC RESYNCHRONIZATION THERAPY
McCULLOCH, Andrew D.,KRISHNAMURTHY, Adarsh,VILLONGCO, Christopher,KRUMMEN, David,NARAYAN, Sanjiv,OMENS, Jeffrey,KERCKHOFFS, Roy
申请号：
EP14862497
公开号：
EP3068484A4
申请日:
2014.11.14
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
in alternative embodiments, provided are compositions, medical devices or products of manufacture, systems, diagnostic tools, and methods, including computer implemented methods, for predicting the response of patients with dyssynchronous heart 10 failure (DHF) to cardiac resynchronization therapy (CRT), comprising: measuring or determining the fraction of the LV/septum performing negative work (MNW) and measuring or determining the coefficient of variation of external work density (COVW), wherein the MNW fraction performing negative work and coefficient of variation COVW (sd/mean) correlated strongly with observed reduction in end-systolic volume after CRT.
