METHODS AND COMPOSITIONS REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS

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专利权人:

LLC;APPLIED BIOSYSTEMS

发明人:

DAVID BROWN,LANCE FORD,RICHARD JARVIS

申请号：

US14078344

公开号：

US20140179762A1

申请日:

2013.11.12

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include kits that include reagents for producing or generating siRNA pools. The present invention further concerns methods using polypeptides with RNase III activity for generating siRNA mixtures or pools that effect RNAi, including the generation of a number of RNA molecules to the same target gene.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/