INDUSTRY-ACADEMIC COOPERATION FOUNDATION; CHOSUN UNIVERSITY
发明人:
PARK, Yoonkyung,박윤경
申请号：
KRKR2015/000386
公开号：
WO2015/108333A1
申请日:
2015.01.14
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to a novel analogue antibiotic peptide derived from a CM-MA peptide and a use thereof. Specifically, novel antibiotic peptides represented by SEQ ID NO: 2 to SEQ ID NO: 7 (CAM 1 to CMA 6) were synthesized by using a CM-MA antibiotic peptide, in which amphiphilic cecropin A (CA) and magainin 2 (MA) are conjugated, as a template. The synthesized antibiotic peptide exhibits antibiotic activity on gram-positive bacteria and gram-negative bacteria and low cytotoxicity on human red blood cells and human normal cell lines (HaCaT), and thus the antibiotic peptide of the present invention can be favorably used as an active ingredient of an antibiotic agent, a cosmetic composition, a food additive, a feed additive, and a biological pesticide.La présente invention concerne un nouvel analogue de peptide antibiotique dérivé dun peptide CM-MA et son utilisation. Plus précisément, de nouveaux peptides antibiotiques représentés par SEQ ID NO: 2 à SEQ ID NO: 7 (CAM 1 à CMA 6) ont été synthétisés au moyen dun peptide antibiotique CM-MA, dans lequel une cécropine A amphiphile (CA) et une magainine 2 (MA) sont conjuguées, comme matrice. Le peptide antibiotique synthétisé présente une activité antibiotique sur les bactéries gram-positif et les bactéries gram-négatif et une faible cytotoxicité sur les globules rouges humains et les lignées cellulaires normales humaines (HaCaT), et ainsi le peptide antibiotique selon la présente invention peut être utilisé de manière favorable comme principe actif dun agent antibiotique, dune composition cosmétique, dun additif alimentaire, dun additif daliments pour animaux et dun pesticide biologique.본 발명은 CM-MA 펩타이드로부터 유래된 신규한 유사체 항생 펩타이드 및 이의 용도에 관한 것으로, 구체적으로 양친화성을 갖는 세크로핀(cecropin A, CA)과 마가이닌(magainin 2, MA)을 접합한 CA-MA 항생 펩타이드를 주형으로 하여, 서열번호 2 내지 서열번호 7로 기재되는 신규한 항생 펩타이드를 합성하였고(CMA 1 내지 CMA 6), 상기 합성된 항생 펩타이드는 그람양성균 및 그람음성균에 대한 항균활성을 나타내면서 인간 적혈구세포 및 인간 정상 세포주(HaCaT)에 대하여 낮은 세포독성을 나타내므로, 본 발명의 항생 펩타이드는 항균용 항생제, 화장료 조성물
