BONGARTZ, JEAN-PIERRE ANDRE MARC,MEERPOEL, LIEVEN,BOECKX, GUSTAAF MARIA,VAN LOMMEN, GUY ROSALIA EUGEEN,BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR,OBRECHT, DANIEL,ERMERT, PHILIPP,LUTHER, ANATOL
申请号：
CA2687912
公开号：
CA2687912C
申请日:
2008.06.05
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention further relates to a DGAT inhibitor of formula (I), including any stereochemically isomeric form thereof, wherein A represents CH or N； the dotted line represents an optional bond in case A represents a carbon atom； X represents -NRx -C(=O)-； -Z-C(=O)-； -Z-NRx -C(=O)-； -S(=O)p-； C(=S)-； -NRx -C(=S)-； -Z-C(=S)-； -Z-NRx -C(=S)-； -O-C(=O)-； -C(=O)-C(=O)-； R1 represents a 5-membered monocyclic heterocycle containing at least 2 heteroatoms； a 6-membered aromatic monocyclic heterocycle； or a 5-membered heterocycle containing at least 2 heteroatoms fused with phenyl, cyclohexyl or a 5-or 6-membered heterocycle； wherein each of said heterocycles may optionally be substituted； R2 represents R3； R3 represents C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms,wherein said C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzo- dioxinyl, 1,3-benzodioxolyl,2,3-dihydrobenzofuranyl or 6-membered aromatic heterocycle may optionally be substituted； a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.
