NEW SALT AND MEDICAL USE农业专利-农业学术服务平台

发明人:: ALI, ZAHID,阿里萨赫德,阿里薩赫德,BUTCHER, KENNETH JOHN,巴雀肯尼斯约翰,巴雀肯尼斯約翰,BUTT, RICHARD PHILIP,巴特理查飞利浦,巴特理查飛利浦,FELSTEAD, STEPHEN JOHN,菲尔斯泰德史蒂芬约翰,菲爾斯泰德史蒂芬約翰,GLATT, SOPHIE,葛雷特索菲,葛雷特索菲,MCKERNAN, RUTH

摘要：: The invention provides 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide or a pharmaceutically acceptable salt thereof for the treatment of a disease associated with elevated blood uric acid levels, such as hyperuricemia or gout.In another aspect the invention provides the tosylate salt of 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide.本發明提供4-[2-(5-胺基-1H-吡唑-4-基)-4-氯苯氧基]-5-氯-2-氟-N-(1,3-噻唑-4-基)苯磺醯胺或其醫藥上可接受之鹽,其用於治療與高血尿酸含量相關之疾病,例如高尿酸血症或痛風。在另一態樣中,本發明提供4-[2-(5-胺基-1H-吡唑-4-基)-4-氯苯氧基]-5-氯-2-氟-N-(1,3-噻唑-4-基)苯磺醯胺之甲苯磺酸鹽。