Maria G. Pau,Lennart Holterman,Jorn Kaspers,Antonius J. H. Stegmann
申请号：
US12928044
公开号：
US08097453B2
申请日:
2010.12.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different Plasmodium infections, such as infections by P. falciparum or P. yoelii. Codon-optimized circumsporozoite genes are disclosed. Replication-defective adenoviruses may be used, derived from serotypes that encounter low titers of neutralizing antibodies. Also described is the use of different adenoviral serotypes that are administered to elicit a strong immune response, either in single vaccination set-ups or in prime-boost set-ups in which compositions based on different serotypes can be applied.
