Horse hoof protection against thrush conditions is obtained by depositing onto the horse hoof bottom wall a synthetic organic resin such as a urethane resin through which a medicament that does not block cure of the resin has been, distributed for continuing hoof wall contact. The resin is suitably free flowing into place, conforms to the contours of the hoof bottom wall, and adheres to the wall when cured. The protection by the resin is resilient and softer than the hoof wall and acts to cushion the hoof against shock.