от имени которой выступает Министерство Обороны Российской Федерации (RU);Российская Федерация
发明人:
Дятлов Иван Алексеевич (RU),Сомов Алексей Николаевич (RU),Дунайцев Игорь Анатольевич (RU),Копылов Павел Христофорович (RU),Иванов Сергей Андреевич (RU),Борзилов Александр Иосифович (RU),Анисимов Андре
申请号：
RU2015152419
公开号：
RU2015152419A
申请日:
2015.12.07
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: biotechnology.SUBSTANCE: invention relates to the field of biotechnology, in particular, to a recombinant vaccine preparation of prolonged action for the prevention of plague. This vaccine preparation contains biodegradable polymers and recombinant purified antigens of the plague microbe F1 and V. Vaccine preparation is a mixture of particles, consisting of aluminum hydroxide with sorbed V and F1 antigens and microcapsules. These microcapsules consist of a porous core formed by a dried gel from a suitable water-soluble polymer, with the dry protein antigen V or F1 distributed therein in different particles in a solid polymer shell of a hydrophobic polymer of poly-D, L-lactide or poly-D, L-lactide-co-glycolide and Tween 20 surfactant. Present invention also relates to a process for the preparation of said vaccine preparation.EFFECT: invention makes it possible to obtain a long-acting vaccine preparation for the prevention of plague.2 cl, 9 ex, 7 tbl
