Peter Kumpalume,Oliver Schon,Christine Patricia Donahue,Ghotas Evindar,David I. Israel,David Paolella,Letian Kuai,Ninad V. Prabhu
申请号：
US15698020
公开号：
US09938243B2
申请日:
2017.09.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
