A pharmaceutical composition comprising: 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-ben zyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)- benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof and N-((S)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-is onicotinamide or a pharmaceutically acceptable salt and/or solvate thereof.Una composición farmacéutica que comprende 3-(1-{3-[5-(1-metil-pip eridin-4-ilmetoxi)-pirimidin-2-il]-bencil}-6-oxo-1,6-dihidro-piri dazin-3-il)-benzonitrilo o una de sus sales y/o solvatos farmacéuticamente aceptables y N-((S)-2,3-dihidroxi-propil)-3-(2-f luoro-4-yodo-fenilamino)- isonicotinamida o una de sus sales y/o solvatos farmacéuticamente aceptables.