Plaque type determination devices, systems, and methods. In at least one exemplary embodiment of a device for assessing composition of a plaque of the present disclosure, the device comprises an elongate body having a longitudinal axis and a distal end, a first excitation electrode and a second excitation electrode located along the longitudinal axis of the body near the distal end of the elongate body, and a first detection electrode and a second detection electrode along the longitudinal axis of the body and in between the first and second excitation electrodes, wherein when a current source in communication with at least one of the first excitation electrode and the second excitation electrode applies current thereto to facilitate measurement of two or more conductance values within a vessel containing at least part of the elongate body at or near a plaque site, a plaque type determination can be made based upon a calculation of tissue conductance using at least one of the two or more conductance values.
