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Virus-containing formulation and use thereof
专利权人:
TRANSGENE SA
发明人:
Sene, Claude,Chasle, Mélina
申请号:
NZ70732813
公开号:
NZ707328A
申请日:
2013.10.02
申请国别(地区):
NZ
年份:
2018
代理人:
摘要:
The present invention relates to formulation comprising (i) at least one virus-based material, (ii) at least one polymer selected from the group of polyvinylpyrrolidone and copovidone, and mixtures thereof, (iii) at least one disaccharide, (iv) arginine and glutamate, (v) at least one phosphate salt and at least one pharmaceutically acceptable monovalent salt and, optionally (vi) a pharmaceutical acceptable buffer. Such a formulation is particularly suitable for freeze-drying and addresses problems associated with storage of virus-containing formulations, such as breakdown due to thermal degradation. The present invention also relates to the corresponding dry product, as well as its preparation process. The present invention also relates to a reconstituted material comprising said dry product, which can be administered to a patient in need thereof. Such formulation and reconstituted material are useful as vaccines, preferably for the treatment and/or the prevention of cancers, infectious diseases and/or autoimmune disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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