Methods for modifying human antibodies by glycan engineering

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专利权人:

ACADEMIA SINICA

发明人:

Wong Chi-Huey,Wu Chung-Yi

申请号：

US201012959351

公开号：

US10087236(B2)

申请日:

2010.12.02

申请国别(地区):

美国

年份:

2018

代理人:

Duane Morris LLP

摘要：

Modified Fc regions of antibodies and antibody fragments, both human and humanized, and having enhanced stability and efficacy, are provided. Fc regions with core fucose residues removed, and attached to oligosaccharides comprising terminal sialyl residues, are provided. Antibodies comprising homogeneous glycosylation of Fc regions with specific oligosaccharides are provided. Fc regions conjugated with homogeneous glycoforms of monosaccharides and trisaccharides, are provided. Methods of preparing human antibodies with modified Fc using glycan engineering, are provided.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/