The invention relates to a drug delivery device (1), comprising: - an outer needle sleeve (7)； - a cartridge (2) containing a dosage of a medicament and sealed with a sealing element (2.1) that is arranged across an open distal end of the cartridge (2), - a cartridge carrier (3) adapted to hold the cartridge (2)； - a needle hub (8) adapted to hold a double ended hollow needle (5)； - an inner needle sleeve (4) arranged between the needle hub (8) and the cartridge carrier (3)； - a removable cap (6) coupled to the inner needle sleeve (4) and adapted to cover and seal the needle (5)； and - a first locking mechanism (L1) adapted to lock the inner needle sleeve (4) against axial movement in the proximal direction (P) with respect to the cartridge carrier (3) in an initial state (S1), wherein in the initial state (S1) the needle (5) is spaced from the cartridge (2) in the distal direction (D)； wherein the first locking mechanism (L1) is releasable by a rotational movement of the cap (6) with respect to the outer needle sleeve (7).本發明涉及一種藥物輸送裝置(1)，包括：- 外部針套筒(7)；- 藥筒(2)，該藥筒(2)包含一定劑量的藥劑並且用密封元件(2.1)密封，該密封元件(2.1)跨越所述藥筒(2)的開放遠端配置，- 藥筒托架(3)，該藥筒托架(3)適於保持所述藥筒(2)；- 針座(8)，該針座(8)適於保持雙頭空心的針(5)；- 內部針套筒(4)，該內部針套筒(4)配置在該針座(8)和該藥筒托架(3)之間；- 可移除的帽(6)，該帽(6)聯接到所述內部針套筒(4)，並且適於覆蓋和密封該針(5)；- 第一鎖定機構(L1)，所述第一鎖定機構(L1)適於在起始狀態(S1)鎖定所述內部針套筒(4)，防止相對於所述藥筒托架(3)沿近側方向(P)軸向移動，其中，在起始狀態(S1)下，該針(5)與該藥筒(2)沿遠側方向(D)是分開的；其中，該第一鎖定機構(L1)能夠通過該帽(6)相對於該外部針套筒(7)的旋轉運動釋放。
