БРАУН Тиффэни Дж. (US),ЛАФЛЁР Адам С. (US),МАЗИЧ Кеннет (US),ТАУЛЕР Джеффри К. (US),ЧЖАН Цзи (US)
申请号：
RU2015111493
公开号：
RU2015111493A
申请日:
2013.08.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A biocompatible material, including at least one semi-crystalline, hydrolytically degradable polymer, exposed to ionizing radiation at a total dose of from about 30 to about 50 kGy, where the specified biocompatible material contains stabilized free radicals. The biocompatible material according to claim 1, upon contact of which with an aqueous medium stabilized free radicals provide reactive oxidizing particles for a long period of time. The biocompatible material according to claim 1, wherein the specific surface area per unit area of the biocompatible material is from about 0.001 m / g to about 50 m / g. The biocompatible material of claim 1, wherein the polymer is exposed to ionizing radiation at a total dose rate of from about 40 kGray to about 50 kGray. The biocompatible material according to claim 1, wherein the polymer is bioresorbable. The biocompatible material according to claim 5, wherein the polymer is selected from the group consisting of poly (dioxanone), poly (glycolide), poly (lactide) poly (ε-caprolactone), poly (anhydrides) such as poly (sebacic acid), poly (hydroxyalkanoates), such as poly (3-hydroxybutyrate), any of these copolymers and combinations thereof. 7. The biocompatible material according to claim 2, wherein said reactive oxidizing particles are selected from the group consisting of superoxide, hydrogen peroxide, singlet oxygen, hydroxyl radical, perhydroxyl radical, peroxynitrite, hypochlorite, and combinations thereof. The biocompatible material of claim 1, further comprising a nitrogen-containing compound that1. Биосовместимый материал, включающий по меньшей мере один полукристаллический, гидролитически разлагаемый полимер, подвергнутый воздействию ионизирующего излучения при общей дозе от приблизительно 30 до приблизительно 50 кГрэй, где указанный биосовместимый материал содержит стабилизированные свободные радикалы.2. Биосовместимый материал по п. 1, при контактировании которого с водной средой стабилизированные свободные радика
